Are antihistamines effective for prolonged non-specific cough in children?
The three included studies were different in several ways. There was some clinical heterogeneity in the participants of the studies (different age groups), all of three studies used a different type of antihistamine, and in two studies children had allergic rhinitis arguably antihistamines would be more efficacious in these children.
Non-specific cough is defined as non-productive cough in the absence of identifiable respiratory disease or known aetiology. It is a common condition, and children are treated with a variety of therapies, including antihistamines.