Do antihypertensive agents prevent diabetic kidney disease?
The main limitation of this study was that the effects of blood pressure lowering agents on end-stage kidney disease could not be ascertained, possibly due to the slowly progressive nature of diabetic kidney disease, and the resultant low incidence of end-stage kidney disease in the population. The risk of cough was significantly increased with ACE inhibitors when compared with placebo.
Many people with diabetes (around 20% to 60%) are affected by hypertension and need drugs to treat this condition. Many people with diabetic kidney disease (20% to 40%) go on to develop end-stage kidney disease, and many others die from heart disease or other circulatory problems before end-stage kidney disease develops