How effective is antimicrobial prophylaxis for the prevention of postoperative surgical wound infection (SWI) in patients undergoing colorectal surgery?
The antibiotic(s) given must cover both aerobic and anaerobic bacteria. Further research is required to establish the optimal timing and duration of dosing, and frequency of longer term adverse effects, such as Clostridium difficile pseudomembranous colitis.
Abdominal SWI in patients having operations on the large intestine occurs in about 40% of patients if antibiotics are not given. This risk can be greatly diminished by the administration of antibiotics prophylactically before surgery.