How effective are pharmacological interventions for the treatment of alcohol withdrawal syndrome (AWS)?
The quality of evidence was high for 3% of the results, moderate for 28%, low for 48% and very low for 20%. No definitive conclusions about the effectiveness and safety of benzodiazepines were possible, because of the heterogeneity of the trials, both in interventions and in the assessment of outcomes.
Alcohol abuse and dependence represents a very serious health problem worldwide, with major social, interpersonal and legal consequences. There is little research data on the comparative effectiveness and cost–benefit of pharmacological treatments.