How effective are inhaled short-acting beta 2 agonists (SABA) and long-acting beta 2 agonists (LABA) in the pretreatment of children and adults with exercise-induced asthma or exercise-induced bronchoconstriction?
Most of the studies addressed the effect of giving a single beta 2 agonist treatment before exercise and recorded the effect on lung function following exercise. Only 8 focused on longer treatment. Long-term use of both SABA and LABA induced the onset of tolerance and decreased the duration of drug effect, even after a short treatment period.
It is well known that physical exercise can trigger asthma symptoms and can induce bronchial obstruction in people without clinical asthma. International guidelines on asthma management recommend the use of beta 2 agonists at any stage of the disease. At present, no consensus has been reached about the efficacy and safety of beta 2 agonists in the pretreatment of exercise-induced asthma and exercise-induced bronchoconstriction.