How effective is chemoradiotherapy for patients with locally advanced cervical cancer?
Currently there is insufficient evidence to suggest that any one treatment type, dose or schedule is better than any other. Acute haematological and gastrointestinal toxicity were increased with chemoradiotherapy, but data were too sparse for an analysis of late toxicity.
Since a 1999 National Cancer Institute clinical alert was issued,¹ chemoradiotherapy has become widely used in treating women with cervical cancer. Two subsequent systematic reviews found interpretation of the benefits was complicated and some important clinical questions were unanswered. This review is a meta-analysis updating individual patient data from all available randomised controlled trials. 1. National Cancer Institute. NCI Issues Clinical Announcement on Cervical Cancer: Chemotherapy plus Radiation Improves Survival. www.nih.gov/news/pr/feb99/nci22.htm 1999.