How effective is citalopram in comparison with tricyclics, heterocyclics, other selective serotonin reuptake inhibitors (SSRIs) and other conventional and non-conventional antidepressants in the acute-phase treatment of major (moderate-to-severe) depression?
Economic analyses were not reported. Sponsorship bias and publication bias had the potential for overestimating treatment effects.
Antidepressant drugs remain the mainstay of treatment in moderate-to-severe depression. During the past 20 years, SSRIs have progressively become the most commonly prescribed antidepressants.