Should I prescribe colchicine for acute gout?
Colchicine commonly causes diarrhoea and/or vomiting (NNH** 1). It is not known whether colchicine is more effective than NSAIDs. In the single small trial reviewed, the dosage prescribed (see Bottom Line section) was higher than current recommendations (maximum of 1mg per day).1 ** NNH = number needed to treat to cause harm in one individual.
Acute gout is one of the commonest rheumatic diseases, affecting up to 10 per cent of adult males. NSAIDs such as diclofenac and naproxen are the treatment of choice.