How beneficial is computerised advice on drug dosage?
The results are based on studies mainly of low quality, concerning a small number of drugs. The advice was system-initiated or user-initiated, and comprised a recommendation on specific drug dosage calculated by the computer. No conclusion could be drawn concerning the logistics of the computerised support and organisation of care aspects. It was not certain these benefits could be achieved with different computer systems in different clinical situations.
Maintaining therapeutic concentrations of drugs with a narrow therapeutic window is a complex task. Several computer systems have been designed to help doctors determine optimum drug dosage. Signiﬁcant improvements in healthcare could be achieved if computer advice improved health outcomes and could be implemented in routine practice in a cost-effective fashion.