How effective is low-dose rate brachytherapy (LDR-BT) in men with localised prostate cancer?
Evidence was based on 1 randomised controlled trial with high risk of bias. Essential requirements of low-risk trials, such as concealment of allocation, description of patient data “lost” to follow-up, and intention-to-treat analysis were not fulfilled. And a priori sample size calculation was not reported.
Localised prostate cancer is a slow growing tumour for many years for the majority of affected men. LDR-BT is short-distance radiotherapy using low-energy radioactive sources, and has been recommended for men with low-risk localised prostate cancer.