How effective are prophylactic antibiotics for meconium-stained amniotic fluid (MSAF) during labour in preventing maternal and neonatal infections?
This review was based on a single study involving 120 participants. The trial was of high methodological quality, based on adequate random allocation concealment. However, the sample size was not big enough to reach any firm conclusions.
Pregnant women with MSAF are more likely to develop maternal complications, including chorioamnionitis and endometritis, and neonatal complications, such as neonatal sepsis, and the need for admission to a NICU. Foetal stress or hypoxia may trigger gasping foetal respirations which result in the aspiration of meconium.