Should thyroxine replacement be prescribed for patients with subclinical hypothyroidism?
Many studies had participants with prior thyroid dysfunction and the studies were small with limited follow-up. Only 2 population-based studies were included. Other studies were in outpatient clinic populations. All bar 3 studies had a mean patient age of 35 years.
The introduction of sensitive assays to determine thyroid stimulating hormone (TSH) concentrations has increased the number of newly diagnosed cases of subclinical hypothyroidism. Subclinical hypothyroid disease is the most common condition found during thyroid function screening.