How effective are antibiotics for treating Shigella dysentery?
There was insufficient evidence to consider any class of antibiotic superior in efficacy in treating Shigella dysentery, but heterogeneity for some comparisons limits confidence in the results. Most of the trials had methodological limitations. These included inadequate reporting of the generation of allocation sequence, inadequate allocation concealment, and lack of blinding. The most common source of bias was failure to report outcome details for participants who were randomised but in whom Shigella could not be isolated from stool culture.
Shigellosis is a bacterial infection of the colon that can cause diarrhoea and dysentery and may lead to death. It occurs mainly in low and middle-income countries where overcrowding and poor sanitation exist, and may lead to around 1.1 million deaths per year globally, mostly in children under five years. Mild symptoms are self-limiting but in more severe cases, antibiotics are recommended for eradication and preventing relapse.