How effective are loop diuretics in the treatment of primary hypertension?
The BP lowering effect is likely to be an overestimate due to the high risk of bias in the included studies. The review did not provide a good estimate of the incidence of associated harms because of the short duration of the trials (mean duration of 8.8 weeks) and the lack of reporting of adverse effects in many of the trials.
Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity. Loop diuretics are indicated and used as antihypertensive drugs but a systematic review of their blood pressure lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from randomised controlled trial evidence has not been conducted.