How effective are nicotine replacement therapy (NRT), bupropion, varenicline, cytisine and nortriptyline in achieving longterm abstinence (six months or longer) from smoking?
Although there was a marginal increase in the likelihood of seizures while taking bupropion, there were no increased risks of neuropsychiatric or heart and circulatory problems. The evidence for the safety of varenicline is still under investigation, but there was no evidence from the trials that it was linked to an increase in neuropsychiatric or heart and circulatory problems.
Smoking is a main cause of early death throughout the world. There are a number of medications which can help people to quit smoking. Three of these - NRT, bupropion, and varenicline - are licensed for this purpose in the US and Europe. Cytisine (similar to varenicline) is licensed for use in Russia and Eastern Europe.