How effective is nebulised hypertonic saline solution in infants with acute viral bronchiolitis?
Three trials did not use analysis on an intention-to-treat basis. The sample size of the review was relatively small, and the statistical power of the studies may have been sufficient for some but not for other outcome measures. The optimal delivery intervals and concentration of saline, and the most effective delivery devices remain to be determined.
Acute viral bronchiolitis is the most common lower respiratory tract infection in infants. The standard treatment remains supportive care. Nebulised hypertonic saline solution may reduce airway oedema and mucus plugging, the main pathological changes, and decrease airway obstruction.