Nicotine receptor partial agonists help people stop smoking

Clinical question: 
How effective are nicotine receptor partial agonists in helping people to stop smoking?
Bottom line: 
Varenicline increases the odds of quitting smoking approximately three-fold compared with placebo (NNT 5–12 for abstinence at 52 weeks). The number of people stopping smoking with varenicline is significantly higher than with bupropion (NNT 9–24), and with a lower risk of serious adverse effects. Cytisine may also increase the chances of quitting, but the evidence at present is inconclusive.
Caveat: 
The main adverse effect of varenicline is nausea, mostly at mild to moderate levels. Nausea usually subsides over time and has little effect on discontinuation rates.
Context: 
Smoking is the most preventable cause of premature death, accounting for 17 per cent of all deaths in some developing countries.
Review CD#: 
CD006103
PEARLS No: 
2
Date: 
July, 2007
Authored by: 
Brian R McAvoy
File: