Are cannabinoids clinically effective in the treatment of dementia?
Only 1 small study met the inclusion criteria. The lack of quantitative data and the unclear risk of bias in key domains of this study mean no useful conclusions can be drawn from this review.
There is increasing evidence the cannabinoid system may regulate neurodegenerative processes, such as excessive glutamate production, oxidative stress and neuroinflammation. Neurodegeneration is a feature common to the various types of dementia and this has led to interest in whether cannabinoids may be clinically useful in the treatment of people with dementia. Recent studies have also shown cannabinoids may have more specific effects in interrupting the pathological process in Alzheimer's disease.