How effective are psychostimulant medications for amphetamine abuse or dependence?
The results of this meta-analysis were obtained from only a few studies with small sample sizes, undertaken to test psychostimulants with different stimulant potencies and restricted ranges of doses. Studies were conducted in the US, Australia or Northern Europe. Generalisation of the results to other countries should be made with caution because social, cultural and health system differences can affect the overall treatment outcome. Furthermore, most studies included participants who were dependent upon methamphetamine because amphetamine dependence is rather infrequent.
Amphetamine dependence is a public health problem with medical, psychiatric, cognitive, legal and socioeconomic consequences. To date, no pharmacological treatment has been approved for this disorder, and psychotherapy remains the mainstay of treatment. In recent years, psychostimulants have been investigated as a possible replacement therapy.