How effective is parecoxib for acute postoperative pain in adults?
NNTs were lower (better) for the intramuscular than the intravenous route, but the 95% confidence intervals were overlapping, indicating no statistically significant differences between these routes of administration in these studies. It is important to recognise that adverse event analysis after single dose administration will not reflect possible adverse events occurring with use of drugs for longer periods of time. In addition, the relatively small number of participants, even when all the trials were combined, is insufficient to detect rare but serious adverse events (wound infection, cerebrovascular and cardiovascular events, and renal dysfunction).
Parecoxib was the first COX-2 available for parenteral administration, and may, given intravenously or intramuscularly, offer advantages over oral medication when patients have nausea and vomiting or are unable to swallow, such as in the immediate postoperative period.