Proton pump inhibitors (PPPIs) most effective treatment for oesophagitis

Clinical question: 
What is the most effective treatment for reflux oesophagitis?
Bottom line: 
Proton pump inhibitor (PPI) therapy is the most effective treatment for short-term (8wks) management of gastro- oesophageal reflux disease (GORD) - NNT= 1 to 2 (for PPI vs placebo). PPI better than H2 receptor antagonist (H2RA) but both superior to placebo. There is a paucity of evidence on prokinectic therapy but no evidence that it is superior to placebo.
Caveat: 
In equivalent dosage different PPI preparations do not show statistically significant differences in their healing effects. Although there was an apparently higher disease persistence rate at the end of the treatment with double dose PPI compared to standard dose, this difference was not statistically significant.
Context: 
GORD is a common problem with an estimated prevalence of 20% in adults. PPIs and H2RAs relieve symptoms by reducing acid secretion in the stomach.
Review CD#: 
CD003244
PEARLS No: 
27
Date: 
May, 2007
Authored by: 
Brian R McAvoy