Skin grafting effective for venous leg ulcers

Clinical question: 
How effective is bilayer artificial skin grafting under compression in venous skin ulcers?
Bottom line: 
Applying bilayer artificial skin in conjunction with compression bandaging increases the chance of healing a venous ulcer compared with compression and simple dressing (NNT = 5 for 6 months’ treatment).
Caveat: 
There was not enough evidence to determine whether other types of skin grafting, such as xenografts (preserved skin from other animals such as pigs) increased the healing of venous ulcers.
Context: 
Venous leg ulcers are a recurrent, chronic, disabling condition, affecting up to 1 in a 100 adults at some time. Prevalence increases with age, and is higher among women. Skin grafts may be taken, or grown into a dressing, from the patient’s own uninjured skin (autografts), or applied as a sheet of bio-engineered skin grown from donor cells (allograft).
Review CD#: 
CD001737
PEARLS No: 
35
Date: 
May, 2007
Authored by: 
Brian R McAvoy