How effective is acyclovir for treating primary herpetic gingivostomatitis (PHG)?
Only 2 trials, one with 72 participants and the other with 20 participants, were included in this review. The second study failed to report several methodological items and was inconsistent in its reporting of the outcomes measured.
PHG is a highly contagious infection of the oral cavity which is caused by the herpes simplex virus. Only about 5-10% of patients initially infected with the virus develop clinical lesions. It is prevalent in children and adolescents and sometimes can cause uncomfortable symptoms including eating and drinking difficulties and, rarely, life threatening encephalitis.