How effective is metformin added to insulin therapy in the management of type 1 diabetes mellitus in adolescents?
Only 2 trials, involving 3 months of treatment, could be included. Meta-analysis was not possible due to the clinical and methodological heterogeneity of data. No data on health-related quality of life, all-cause mortality or morbidity are currently available.
Metabolic control, as measured by HbA1c, often deteriorates during puberty in young people with type 1 diabetes, possibly due to the development of insulin resistance. This creates a great need for alternative therapeutic strategies for these patients.