How effective are systemic antibiotics and antiseptics in healing venous ulcers?
The regimen used with cadexomer iodine was intensive and hospital based, and so these findings may not have been generalisable to most everyday clinical settings. Further good quality research is required before definitive conclusions can be made about the effectiveness of systemic antibiotics and topical agents, such as povidone iodine, peroxide-based preparations, ethacridine lactate and muciprocin. In the light of the increasing problems of bacterial resistance to antibiotics, current prescribing guidelines recommend antibacterial preparations should only be used in cases of defined infection and not for bacterial colonisation.
Venous leg ulcers affect up to 1% of adults in developed countries at some point during their life. Many of the wounds are colonised by bacteria or show signs of clinical infection, which may delay ulcer healing.