How effective is topical glyceryl trinitrate (GTN) for rotator cuff disease?
The inclusion criteria varied between studies and the selective reporting of outcomes limited the analysis of the available data. The effects on pain of GTN patches (1.25mg/day), along with rehabilitation instruction (such as exercise) and of GTN patches (5mg/day) compared to injection with corticosteroid and painkillers, were not reported by the studies included in the review. It is uncertain whether GTN patches (5mg/day) eliminate symptoms of rotator cuff disease because of the very low quality of the evidence. Improvement in people's physical function was not measured by any of the studies included in the review.
Topical GTN has been used to treat chest pain for many years, and has been proposed as a promising treatment for muscle and tendon injuries. For treatment of soft tissue conditions, GTN is delivered topically, through the skin, using medicated patches.