How effective are vaccines for preventing rotavirus diarrhoea?
All the included trials were placebo controlled, which means there are no data directly comparing Rotarix and RotaTeq. The trials provided only limited data for special groups of children, such as preterm infants and malnourished children.
Rotavirus infections cause over half a million deaths per year in children younger than 5 years, especially in low-income and middle-income countries. Since 2009, the World Health Organization has recommended rotavirus vaccination be included in national immunisation programmes, especially in countries with a high burden of diarrhoeal deaths in children younger than 5 years.